Clinical Trials

PSMA-Directed Para-Aortic Radiation Therapy for Oligorecurrent Prostate Cancer

July 30th, 2024 | Clinical Trials

NCT Number: NCT06392295 Phase: PHASE2 Trial Summary: The purpose of this prostate cancer research study is to learn about: – clinicaltrials.gov for more information and locations 1. Improving control of prostate cancer using radiation therapy, delivered to the para-aortic and pelvic lymph nodes, in addition – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): […]

Enzalutamide Implants (Enolen) in Patients With Prostate Cancer

July 30th, 2024 | Clinical Trials

NCT Number: NCT06257693 Phase: PHASE1 Trial Summary: The study is to assess whether the Enolen is safe and delivers anti-androgen medication locally in patients that are planning for radical prostatectomy. – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): Alessa Therapeutics Inc. Acronym:

Relationship bw Image-deriv Features of Intraoperative ICG Visualiz of NVBs During RARP & Functional Outcome

July 30th, 2024 | Clinical Trials

NCT Number: NCT06446648 Phase: EARLY_PHASE1 Trial Summary: This is a pilot, 3 phases open-label feasibility study with the 3rd phase consisting of randomized 2-arm intervention trial, to assess the systematic use of indocyanine green (ICG) in subjects with pr – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): University of California, Irvine Acronym:

Neoadjuvant SGLT2 Inhibition in High-Risk Localized Prostate Cancer

July 30th, 2024 | Clinical Trials

NCT Number: NCT04887935 Phase: PHASE1 Trial Summary: This is a study of the tolerability and safety of neoadjuvant dapagliflozin for patients with high-risk or very high risk prostatic adenocarcinoma prior to radical prostatectomy. The primary hypothesi – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): Washington University School of Medicine Acronym:

Mevrometostat Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma

July 30th, 2024 | Clinical Trials

NCT Number: NCT03460977 Phase: Phase 1 Trial Summary: A Phase 1 Dose Escalation and Expanded Cohort Study Of PF-06821497 In The Treatment Of Adult Patients With Relapsed/Refractory Small Cell Lung Cancer (SCLC), Castration Resistant P – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): Pfizer Acronym: PF-06821497

A Single-Arm Phase II Study of Neoadjuvant Intensified Androgen Deprivation (Leuprolide and Abiraterone Acetate) in Combination With AKT Inhibition (Capivasertib) for High-Risk Localized Prostate Cancer With PTEN Loss

July 30th, 2024 | Clinical Trials

NCT Number: NCT05593497 Phase: PHASE2 Trial Summary: The purpose of this study is to learn about how an investigational drug intervention completed before doing prostate surgery (specifically, radical prostatectomy with lymph node dissection) may help i – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): VA Office of Research and Development Acronym: SNARE

Testing the Addition of the Drug Apalutamide to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer

July 30th, 2024 | Clinical Trials

NCT Number: NCT04134260 Phase: Phase 3 Trial Summary: This phase III trial studies whether adding apalutamide to the usual treatment improves outcome in patients with lymph node positive prostate cancer after surgery. Radiation therap – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): NRG Oncology Acronym:

Accuracy of 18F-rhPSMA-7.3 PET/ MRI for Prediction of Lymph Node Metastasis in Localized High-Risk Prostate Cancer

July 30th, 2024 | Clinical Trials

NCT Number: NCT06389786 Phase: NA Trial Summary: This clinical trial evaluates the use of an imaging scan (18F-rhPSMA-7.3 positron emission tomography [PET]/magnetic resonance imaging [MRI]) for identifying patients who are at risk of having the – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): Mayo Clinic Acronym:

Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial

July 30th, 2024 | Clinical Trials

NCT Number: NCT04513717 Phase: Phase 3 Trial Summary: This phase III trial compares less intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in treating patients with high risk prostate cancer – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): NRG Oncology Acronym:

Intensive Cholesterol-Lowering and CD8+ T Cells in Prostate Cancer

July 30th, 2024 | Clinical Trials

NCT Number: NCT06437574 Phase: PHASE2 Trial Summary: To test the hypothesis that intensive cholesterol lowering (iCL) therapy has anti-tumor immune modulating activity, the investigators will conduct an open-label, single-arm phase II trial in prostate – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): Cedars-Sinai Medical Center Acronym:

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