Clinical Trials

Bipolar Androgen Therapy (BAT) and Radium-223 (RAD) in Metastatic Castration-resistant Prostate Cancer (mCRPC)

June 23rd, 2023 | Clinical Trials

NCT Number: NCT04704505 Phase: Phase 2 Trial Summary: This is a single-arm, multicenter open label, international, phase II study of Bipolar Androgen Therapy (BAT) plus Radium-223 (RAD) in men with metastatic castration-resistant pros – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Acronym: BAT-RAD

Utility of Hyperpolarized 13C-pyruvate Metabolic Magnetic Resonance Imaging

June 23rd, 2023 | Clinical Trials

NCT Number: NCT04698564 Phase: Phase 2 Trial Summary: This is a two-tiered pilot study in which there will be no randomization and no placebo treatment. This study will be to perform metabolic magnetic resonance imaging on men suspect – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): University of Maryland, Baltimore Acronym:

Multiparametric Magnetic Resonance Imaging of the Prostate to Assess Disease Progression and Genomics in Patients Undergoing Active Surveillance for Prostate Cancer

June 23rd, 2023 | Clinical Trials

NCT Number: NCT04692675 Phase: Not Applicable Trial Summary: Active surveillance (AS) is a standard approach to treat low and intermediate risk prostate cancer. For AS, disease progression is monitored. AS uses biopsies, prostate specific an – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) […]

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

June 23rd, 2023 | Clinical Trials

NCT Number: NCT04644068 Phase: Phase 1|Phase 2 Trial Summary: This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-can – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): AstraZeneca Acronym: PETRA

Brain and Pelvic Floor Muscle Activity of Patients Undergoing Robot-Assisted Radical Prostatectomy

June 23rd, 2023 | Clinical Trials

NCT Number: NCT04646434 Phase: Not Applicable Trial Summary: This trial investigates brain and pelvic floor muscle activity in patients undergoing robot-assisted radical prostatectomy. This trial may help identify the brain waves that are as – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): Roswell Park Cancer Institute Acronym:

A Study of JNJ-69086420, an Actinium-225-Labeled Antibody Targeting Human Kallikrein-2 (hK2) for Advanced Prostate Cancer

June 23rd, 2023 | Clinical Trials

NCT Number: NCT04644770 Phase: Phase 1 Trial Summary: The purpose of this study is to determine the recommended Phase 2 dose(s) (RP2D[s]) of JNJ-69086420 in Part 1 (Dose Escalation) and to determine safety and and preliminary signs – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): Janssen Research & Development, LLC Acronym:

M9241 in Combination With Docetaxel in Adults With Metastatic Castration Sensitive and Castration Resistant Prostate Cancer

June 23rd, 2023 | Clinical Trials

NCT Number: NCT04633252 Phase: Phase 1|Phase 2 Trial Summary: Metastatic castration sensitive and castration resistant prostate cancer (mCSPC and mCRPC) are prostate cancers that have spread to other parts of the body. Use of the drug docetax – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): National Cancer Institute (NCI)|National Institutes of Health Clinical […]

A Study of Focal Salvage High-Dose-Rate Brachytherapy for Prostate Gland Only Recurrence

June 23rd, 2023 | Clinical Trials

NCT Number: NCT04645810 Phase: Early Phase 1 Trial Summary: The purpose of this study is to learn more about what effects the use of high-dose-rate (HDR) brachytherapy on prostate cancer recurrence, seen by AXUMIN PET scan, has on prostate – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): University of Rochester Acronym:

Study of PF-07248144 in Advanced or Metastatic Solid Tumors

June 23rd, 2023 | Clinical Trials

NCT Number: NCT04606446 Phase: Phase 1 Trial Summary: This is an open-label, multi center study to evaluate safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of PF-07248144 and early signs of clinical efficacy of – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): Pfizer Acronym: KAT6

Re-treatment 225Ac-J591 for mCRPC

June 23rd, 2023 | Clinical Trials

NCT Number: NCT04576871 Phase: Early Phase 1 Trial Summary: The purpose of this study is to find out if re-treatment with 225Ac-J591 can be given without severe – clinicaltrials.gov for more information and locations Clinicaltrials.gov Trial Sponsor(s): Weill Medical College of Cornell University Acronym:

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