Intermediate Risk Prostate Cancer

Clinical trials for patients who are diagnosed with intermediate risk prostate cancer: Patients with a diagnosis that includes a PSA 10-20, or Gleason 7, or cancer involves more than one half of one side or both sides of the prostate.  (Stage 1-2)

FPI-2265 (225Ac-PSMA-I&T) for Patients With PSMA-Positive Metastatic Castration-Resistant Prostate Cancer (mCRPC)

NCT Number: NCT06402331
Phase: PHASE2|PHASE3
Trial Summary: This is an open-label, randomized, multicenter study of FPI-2265 (225Ac-PSMA-I&T). The dose optimization Phase 2 part will be investigating the safety, tolerability, and anti-tumor activity of novel – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Fusion Pharmaceuticals Inc.
Acronym: AlphaBreak

High-Risk Metachronous Oligometastatic Prostate Cancer Trial

NCT Number: NCT06212583
Phase: PHASE2
Trial Summary: The purpose of this research study is to compare the effects, good and/or bad, of using the standard of care treatment, hormonal therapy + Stereotactic Ablative Radiation (SABR) to the metastatic lesi – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of California, Davis
Acronym: KNIGHTS

Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer

NCT Number: NCT06305598
Phase: PHASE1
Trial Summary: This phase I trial tests the change in androgen receptor sensitivity, side effects and effectiveness of bipolar androgen therapy, using testosterone, in patients with castration resistant prostate can – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Roswell Park Cancer Institute
Acronym:

Hormone Therapy (Apalutamide) and Image-guided Stereotactic Body Radiation Therapy for the Treatment of Patients With Prostate Cancer, HEATWAVE Trial

NCT Number: NCT06067269
Phase: PHASE2
Trial Summary: This phase II trial evaluates apalutamide in combination with image-guided stereotactic body radiation therapy (SBRT) for the treatment of patients with prostate cancer. Prostate cancer usually needs – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Jonsson Comprehensive Cancer Center
Acronym: HEATWAVE

Geriatric Assessment and Promotores (GAP) Pilot Feasibility Study

NCT Number: NCT06125145
Phase: PHASE2
Trial Summary: The goal of this clinical trial is to test a new way to help older adults who have had cancer. The researchers want to see if a program that assesses participants health and aging is achievable and m – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of California, Davis
Acronym: GAP

Relationship bw Image-deriv Features of Intraoperative ICG Visualiz of NVBs During RARP & Functional Outcome

NCT Number: NCT06446648
Phase: EARLY_PHASE1
Trial Summary: This is a pilot, 3 phases open-label feasibility study with the 3rd phase consisting of randomized 2-arm intervention trial, to assess the systematic use of indocyanine green (ICG) in subjects with pr – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of California, Irvine
Acronym:

Intensive Cholesterol-Lowering and CD8+ T Cells in Prostate Cancer

NCT Number: NCT06437574
Phase: PHASE2
Trial Summary: To test the hypothesis that intensive cholesterol lowering (iCL) therapy has anti-tumor immune modulating activity, the investigators will conduct an open-label, single-arm phase II trial in prostate – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Cedars-Sinai Medical Center
Acronym:

CV CARE: CardioVascular Care in PC Patients

NCT Number: NCT06202820
Phase: NA
Trial Summary: This research is being done to test a program to assess and manage reversible cardiovascular (CV) risk factors in participants with prostate cancer starting androgen deprivation therapy (ADT), with th – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Dana-Farber Cancer Institute
Acronym:

A Trial for a Preliminary Estimate of the Effectiveness of a Novel Theoretical Framework

NCT Number: NCT06461416
Phase: NA
Trial Summary: Aim 1: To determine the preliminary effect sizes of al ActiveHeal EST (Engage-Sustain-Triumph) Program on occupational resilience. – clinicaltrials.gov for more information and locations
* Aim 2: To determine the preliminary effect sizes of ActiveHeal ES – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of Arkansas
Acronym:

Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer

NCT Number: NCT06398639
Phase: EARLY_PHASE1
Trial Summary: The goal of this clinical trial is to evaluate a screening method to detect clinically relevant prostate cancer. This clinical trial is using genetic data to determine a man’s risk of cancer, together – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of Alabama at Birmingham
Acronym: PRS

MRI Guided Prostate Biopsy

NCT Number: NCT06302595
Phase: NA
Trial Summary: This study aims to assess the feasibility of magnetic resonance (MR) guided prostate biopsy using a needle holder frame. This frame is used to help position the needle used for the biopsy. The feasibi – see clinicaltrials.gov for information and location
Clinicaltrials.gov
Trial Sponsor(s): Brigham and Women’s Hospital
Acronym:

Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate CancEr

NCT Number: NCT05948657
Phase:
Trial Summary: This study will be assessing the ability of PSMA-PET CT to determine the absence of clinically significant prostate cancer in patients on active surveillance (AS) with low risk and favorable intermedi – see clinicaltrials.gov for information and location
Clinicaltrials.gov
Trial Sponsor(s): Weill Medical College of Cornell University
Acronym: ESCAPE

PRCT001 Aquablation theraPy Outcomes in pRostate Cancer patienTs

NCT Number: NCT06051942
Phase: NA
Trial Summary: The goal of this clinical trial is to assess the performance and safety of the AQUABEAM Robotic System for the resection and removal of prostate tissue in patients experiencing lower urinary tract sym – see clinicaltrials.gov for information and location
Clinicaltrials.gov
Trial Sponsor(s): PROCEPT BioRobotics
Acronym:

Behavioral Exercise Training to Reduce Cardiovascular Disease Risk

NCT Number: NCT06237179
Phase: PHASE1|PHASE2
Trial Summary: To test the preliminary effectiveness of a home-based exercise training (ET) intervention to improve exercise capacity (VO2 peak & 6-minute walk distance [6MWD]) among prostate cancer (PC) patients – see clinicaltrials.gov for information and location
Clinicaltrials.gov
Trial Sponsor(s): Virginia Commonwealth University
Acronym: EXTRA-PC

A Study to Determine the Preferred Dose of the Drug, Lisinopril, for Preventing Urinary Toxicity Following Radiotherapy for Prostate Cancer

NCT Number: NCT05530655
Phase: Early Phase I
Trial Summary: This study will establish the preferred dose of lisinopril in men with non-metastatic prostate cancer undergoing radiation treatment. This study will also evaluate the effect of lisinopril on urinary – see clinicaltrials.gov for information and location
Clinicaltrials.gov
Trial Sponsor(s): University of Rochester
Acronym:

Rectal Spacer for Prostate Cancer Radiation Image Guidance

NCT Number: NCT05650021
Phase:
Trial Summary: The purpose of the study is to determine if a radiopaque hydrogel rectal spacer, SpaceOAR Vue®, can be used in place of fiducial markers when aligning patients for radiotherapy. The investigator hypo – see clinicaltrials.gov for information and location
Clinicaltrials.gov
Trial Sponsor(s): Milton S. Hershey Medical Center
Acronym:

RecoverPC: Relugolix vs GnRH Agonist in Quality of Life

NCT Number: NCT05765500
Phase:
Trial Summary: This study is testing the way that approved androgen deprivation therapy treatments, Leuprolide and Relugolix, for prostate cancer affect quality of life, blood levels, cholesterol, and blood sugar. T – see clinicaltrials.gov for information and location
Clinicaltrials.gov
Trial Sponsor(s): Dana-Farber Cancer Institute
Acronym:

PReclude Infection EVEnts With No Prophylaxis Transperineal Biopsy 2

NCT Number: NCT04815876
Phase: NA
Trial Summary: Approximately one million transrectal prostate biopsies are performed annually in the U.S., and the risk of post- biopsy infection is increasing due to greater antibiotic resistanc – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Weill Medical College of Cornell University
Acronym: PREVENT2

MRI And GPS Informing Choices for Prostate Cancer Treatment (MAGIC)

NCT Number: NCT05424783
Phase: Not Applicable
Trial Summary: The overarching goal is to prospectively recruit men considering active surveillance for treatment in the MAGIC (MRI And GPS Informing Choices for prostate cancer treatment) Cohort – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Northwestern University
Acronym: MAGIC

Stereotactic Ablative Radiation Therapy for Prostate Cancer

NCT Number: NCT05668351
Phase: NA
Trial Summary: This single arm trial will investigate a novel way to plan and deliver SABR for prostate cancer. Prostate-directed SABR will be high-dose SABR (40 Gy in 5 fractions) with central sparing of the urethr – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Medical University of South Carolina
Acronym: SUPR-SABR

Genomics in Michigan to AdJust Outcomes in Prostate canceR (G-MAJOR) for Men With Newly Diagnosed Favorable Risk Prostate Cancer

NCT Number: NCT04396808
Phase: Not Applicable
Trial Summary: This study seeks to determine the clinical impact of Gene Expression Classifier (GEC) testing in prostate cancer care while also developing a pragmatic approach for improved GEC cl – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of Michigan Rogel Cancer Center
Acronym:

Diet and Physical Activity Intervention for the Prevention of ADT-Induced Metabolic Changes in Patients With Prostate Cancer, TRIPLE-A PILOT Study

NCT Number: NCT04870515
Phase: Not Applicable
Trial Summary: This clinical trial studies the effects of a diet and physical activity intervention on blood measures of lipids and insulin resistance in patients with prostate cancer undergoing – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Fred Hutchinson Cancer Center
Acronym:

PSMA-PET to Guide Prostatectomy

NCT Number: NCT05381103
Phase: Phase 2|Phase 3
Trial Summary: In this study, 288 patients will be randomized 1:1 to either having only the standard of care MRI prior to surgery versus having the standard of care MRI and the PSMA PET scan. PET – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Five Eleven Pharma, Inc.
Acronym:

Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With BRCA1/2 Gene Alterations

NCT Number: NCT05498272
Phase: Phase 2
Trial Summary: Phase 2 open-label, single-arm clinical trial evaluating the efficacy and safety of neoadjuvant olaparib + LHRH agonist administered for 6 months prior to radical prostatectomy (RP – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Rana McKay, MD
Acronym: NePtune

Adaptive Stereotactic Body Radiation Therapy to the Prostate and Pelvic Nodes With Simultaneous Integrated Boost to the MR-detected Nodule for Patients With High-risk and Unfavorable Intermediate-risk Prostate Cancer

NCT Number: NCT05628363
Phase: Not Applicable
Trial Summary: This trial is a prospective clinical trial designed to demonstrate the safety and feasibility of whole-pelvis adaptive prostate stereotactic body radiation therapy (SBRT) with a tu – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Washington University School of Medicine
Acronym:

A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies

NCT Number: NCT05794906
Phase: Phase 3
Trial Summary: Researchers are looking for a better way to treat men at high-risk of biochemical recurrence (BCR) of prostate cancer. BCR means that in men who had prostate cancer and were treated by either surgery – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Bayer
Acronym: ARASTEP

Diffusion Basis Spectrum Imaging of the Prostate

NCT Number: NCT04420702
Phase: Not Applicable
Trial Summary: Diffusion Basis Spectrum Imaging (DBSI) represents a potential leap forward in improving prostate cancer early detection: a non-invasive and accurate imaging test for clinically si – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Washington University School of Medicine
Acronym:

Study of PSMA PET/MR Guided Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost (SBRT-SIB) for High-Intermediate and High Risk Prostate Cancer

NCT Number: NCT04402151
Phase: Phase 2
Trial Summary: This is a single-arm Phase II clinical trial assessing the clinical efficacy of prostate specific membrane antigen (PSMA) PET/MR guided MR-LINAC based SBRT-SIB with planned accrual – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Weill Medical College of Cornell University
Acronym: PSMA SBRT-SIB

RESIST-ADT (Androgen Deprivation Therapy)

NCT Number: NCT04485767
Phase: Not Applicable
Trial Summary: The overall goal of this study is to determine if implementing structured exercises prevent decline in muscle mass, muscle strength and physical function in men with prostate cance – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Dana-Farber Cancer Institute
Acronym:

The Genomic Medicine at VA Study

NCT Number: NCT04331535
Phase: Not Applicable
Trial Summary: This trial will determine the clinical effectiveness of polygenic risk score testing among patients at high genetic risk for at least one of six diseases (coronary artery disease, – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Boston VA Research Institute, Inc.
Acronym: GenoVA

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

NCT Number: NCT04585750
Phase: Phase 1|Phase 2
Trial Summary: This study will assess the safety, tolerability, and efficacy of multiple dose levels of PC14586 alone and in combination with pembrolizumab in participants with advanced solid tumors containing a TP5 – clinicaltrials.gov for more information and locations and locations
Clinicaltrials.gov
Trial Sponsor(s): PMV Pharmaceuticals, Inc
Acronym:

Video Education With Result Dependent dIsclosure

NCT Number: NCT05225428
Phase: Not Applicable
Trial Summary: The overall study objective of this trial study is to identify and evaluate strategies to improve the accessibility of the video education with result dependent disclosure (VERDI) model, increasingly – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Dana-Farber Cancer Institute
Acronym: VERDI

Whole-Food Plant-Based Diet to Control Weight and MetaboInflammation in Overweight/Obese Men With Prostate Cancer

NCT Number: NCT05471414
Phase: Not Applicable
Trial Summary: The study is comparing the effect on weight of providing home-delivered whole-food, plant-based meals versus standard, general nutritional counseling to men with prostate cancer on androgen-deprivatio – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Weill Medical College of Cornell University
Acronym: WFPBD

African Cancer Genome: GMD

NCT Number: NCT05754658
Phase:
Trial Summary: he goal of this study is to develop a comprehensive characterization of genetic and molecular drivers of breast and prostate cancer in individuals of – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Fox Chase Cancer Center
Acronym:

Prostate Resection After Microwave Ablation (PRAMA)

NCT Number: NCT06128525
Phase: NA
Trial Summary: This phase I trial tests the safety of magnetic resonance imaging (MRI)/ ultrasound (US) fusion guided transperineal targeted microwave ablation (TMA) before a radical prostatectomy (RP) and how well – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of Southern California
Acronym:

A Study of Mental Health Care in People With Cancer

NCT Number: NCT06037954
Phase: NA
Trial Summary: The purpose of this study is to look at mental health services for adults with depressed mood who were diagnosed with cancer at the age of 65 or older. This study will compare the usual approach for c – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s):
Acronym:

IS-002 in Prostate Cancer

NCT Number: NCT05946603
Phase: PHASE2
Trial Summary: Phase 2 randomized controlled multi-center study of IS-002, in conjunction with near-infrared (NIR) fluorescence imaging, for identification of prostate cancer during robotic-assisted radical prostate – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s):
Acronym:

Understanding of Genetics by Men at Risk for Prostate Cancer

NCT Number: NCT04550845
Phase: NA
Trial Summary: With this greater certainty regarding prognosis, men with localized prostate cancer are now equipped with make better treatment planning decisions. This study is designed to investigate the understand – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s):
Acronym:

INTREPId (INTermediate Risk Erection PreservatIon Trial)

NCT Number: NCT04025372
Phase: Phase 2
Trial Summary: This research study is comparing the use of a new form of hormonal therapy used with radiation as a possible treatment for intermediate risk prostate cancer. More specifically, thi – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s):
Acronym:

Two Fraction Prostate SBRT With DIL SIB

NCT Number: NCT05864196
Phase: PHASE1
Trial Summary: Phase I/Ib, single arm trial of Two-Fraction Stereotactic Body Radiation Therapy (SBRT) with an MRI directed, dominant intraprostatic lesion (DIL), simultaneous integrated boost (SIB) based on genomic – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): NYU Langone Health
Acronym:

Collection of Blood From Patients With Cancer

NCT Number: NCT00034216
Phase:
Trial Summary: This study will collect blood from patients with cancer to study the level of cells which decrease the immune response (suppressor cells) before and after chemotherapy. Patients 18 years of age and ol – clinicaltrials.gov for more information and location
Clinicaltrials.gov
Trial Sponsor(s): National Cancer Institute (NCI)
Acronym:

PROMISE Registry: A Prostate Cancer Registry of Outcomes and Germline Mutations for Improved Survival and Treatment Effectiveness

NCT Number: NCT04995198
Patient Summary
Phase:
Trial Summary: PROMISE aims to create a comprehensive nationwide registry of prostate cancer patients with germline pathogenic variants by prospectively screening approximately 5,000 subjects with a confirmed prostate cancer diagnosis, either through tissue biopsy, PSA greater than 100 ng/dL and/or radiographic evidence of disease and receiving systemic therapy for prostate cancer. Patients at all stages of disease will be welcome to participate in the PROMISE Registry. – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Prostate Cancer Clinical Trials Consortium
Acronym:

Pre-operative Education Modalities to Decrease Opioid Use

NCT Number: NCT04933084
Phase: NA
Trial Summary: This is a triple-armed, randomized, controlled, non-blinded trial to study the effect of preoperative patient education in conjunction with a limited opioid peri-operative analgesia program on post-op – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Benaroya Research Institute
Acronym:

Optimization of Prostate Biopsy – Micro-Ultrasound Versus MRI

NCT Number: NCT05220501
Phase: NA
Trial Summary: OPTIMUM is a study designed to compare the ability of ultra-high resolution transrectal micro-ultrasound (microUS) and multiparametric MRI (mpMRI)/US fusion to guide prostate biopsy. – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Sunnybrook Health Sciences Centre
Acronym: OPTIMUM

Clinical Trial of Approaches to Prostate Cancer Surgery

NCT Number: NCT05155501
Phase: NA
Trial Summary: This is a prospective, randomized controlled trial to compare cancer control and health-related quality of life following pelvic fascia-sparing radical prostatectomy versus standard radical prostatect – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Weill Medical College of Cornell University
Acronym: PARTIAL

MRI Risk Maps for Prostate Cancer Diagnosis Using Targeted Biopsy

NCT Number: NCT05710380
Phase: NA
Trial Summary: Doctors leading this study hope to learn about a software that researchers at the University of Chicago have developed to help analyze radiographic images (different techniques for taking images that – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of Chicago
Acronym:

Physical Therapy for Men Undergoing Prostatectomy

NCT Number: NCT02558946
Phase: NA
Trial Summary: The purpose of this study is to determine if pelvic floor muscle training with a physical therapist before and after surgery will improve health-related quality of life following robot-assisted radica – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Indiana University
Acronym:

Transrectal Ultrasound Robot-Assisted Prostate Biopsy

NCT Number: NCT02871726
Phase: NA
Trial Summary: Prostate cancer (PCa) is the most common non-dermatologic malignancy in U.S. men. Transrectal ultrasound (TRUS)-guided prostate biopsy is a commonly used diagnostic procedure for men with an elevated – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Johns Hopkins University
Acronym:

Evaluation of PSMA in HER2- AR+ Metastatic Breast Cancer

NCT Number: NCT04573231
Phase: PHASE2
Trial Summary: The purpose of this research is to determine the expression of prostate specific membrane antigen (PSMA) in human epidermal growth factor receptor 2 (HER2)-negative, androgen receptor (AR)-positive me – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of Wisconsin, Madison
Acronym:

Light Therapy and Occupational Therapy Fatigue Management-Based Intervention for Patients With Genitourinary Cancers

NCT Number: NCT05519878
Phase: Not Applicable
Trial Summary: This clinical trial evaluates light therapy and occupational therapy in improving cancer related fatigue (CRF) patients with genitourinary cancers. Light therapy is a non-pharmacological and evidence- – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): City of Hope Medical Center|National Cancer Institute (NCI)
Acronym:

Water Vapor Ablation for Localized Intermediate Risk Prostate Cancer

NCT Number: NCT05683691
Phase: Not Applicable
Trial Summary: The purpose of this study is to evaluate the safety and efficacy of the Vanquish Water Vapor Ablation Device (“Vanquish”) in treating subjects with Gleason Grade Group 2 (GGG2) localized intermediate- – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Francis Medical Inc.
Acronym: VAPOR 2

Daily Adaptive Radiation Therapy Using an Individualized Approach for Prostate Cancer

NCT Number: NCT05804318
Phase: Not Applicable
Trial Summary: This trial is a prospective, single-arm, multi-center clinical trial designed to assess whether adaptive radiotherapy with urethral sparing for low to intermediate risk localized prostate cancer will – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Varian, a Siemens Healthineers Company
Acronym: ARTIA-Prostate

A Study of [225Ac]-FPI-2059 in Adult Participants With Solid Tumours

NCT Number: NCT05605522
Phase: Phase 1
Trial Summary: This is a first-in-human Phase 1 clinical trial designed to investigate the safety, tolerability, pharmacokinetics, and biodistribution of [225Ac]-FPI-2059 and [111In]-FPI-2058 – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Fusion Pharmaceuticals Inc.
Acronym:

Anti-inflammatory Drugs and Serum Prostate-Specific Antigen Test

NCT Number: NCT05629494
Phase: Phase 4
Trial Summary: Prostate cancer is the most frequently diagnosed cancer in men in the Unites States. Nearly 1 million prostate biopsy procedures are performed in the United States annually and ele – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Albany Medical College
Acronym: ADAPT-PSA

Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy

NCT Number: NCT05597878
Phase: Phase 2|Phase 3
Trial Summary: The objective of this study is to conduct a randomized clinical trial to evaluate an opioid versus an opioid-free pathway of perioperative use of ketamine, ketorolac, and IV acetam – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Wake Forest University Health Sciences
Acronym:

Wrist Cooling for Hot Flashes Clinical Trial

NCT Number: NCT05595213
Phase: NA
Trial Summary: This pilot randomized double blind controlled crossover study aims to determine the impact of two wrist cooling devices on symptom control of hot flashes in adult men with prostate – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Boston University
Acronym:

Improving Germline Testing in At-Risk Patients With Prostate Cancer

NCT Number: NCT05470036
Phase: Not Applicable
Trial Summary: A quality improvement initiative to improve rates of germline testing among men with prostate cancer through the use of an in-clinic educational sessi – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of California, San Diego
Acronym: IMPRINT

T-Cell Clonality After Stereotactic Body Radiation Therapy Alone and in Combination With the Immunocytokine M9241 in Localized High- and Intermediate-Risk Prostate Cancer Treated With Androgen Deprivation Therapy

NCT Number: NCT05361798
Phase: Phase 2
Trial Summary: Prostate cancer is often treated with radiation and ADT (ADT is androgen deprivation therapy). Up to 30% of these cancers recur within 5 years of treatment. Researchers want to see – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
Acronym:

Patient-Reported Erectile Recovery and Quality of Life Outcomes With Lyopreserved Placental Tissue Applied Directly Over Neurovascular Bundle During Nerve Sparing Radical Prostatectomy Versus Standard of Care

NCT Number: NCT05366842
Phase: Phase 2
Trial Summary: Surgical implantation of Lyopreserved Placental Tissue (LPT) is FDA approved and has been used extensively in wound care. The use is expanding and more recently, LPT has been used – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Johns Hopkins University
Acronym:

UroLift System With SAbR for Prostate Cancer and BPH

NCT Number: NCT05311527
Phase: PHASE1
Trial Summary: Confirming safety of combining UroLift System prior to SAbR for patients with newly diagnosed prostate cancer and a history of BPH, by measuring the acute complication rate of UroL – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of Texas Southwestern Medical Center
Acronym:

Social Risk Factors and Discrimination in Cancer Survivorship

NCT Number: NCT05301114
Phase: NA
Trial Summary: The objective of the proposed study is to scale social risk factor screening and referral for cancer survivors and to solidify information exchange between clinical and community s – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Medstar Health Research Institute
Acronym:

Image-Guided (68Ga-PSMA-11 PET/CT) Prostate Biopsy for the Diagnosis of Prostate Cancer in Men With Prior Negative/Inconclusive Biopsy

NCT Number: NCT05160597
Phase: Early Phase 1
Trial Summary: This early phase I trial studies how well an image-guided prostate biopsy using the imaging agent 68Ga-prostate-specific membrane antigen (PSMA)-11 with a positron emission tomogra – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Jonsson Comprehensive Cancer Center
Acronym:

A Study of Stereotactic Body Radiation Therapy (SBRT) Without Androgen Deprivation Therapy (ADT) in People With Unfavorable Intermediate-Risk Prostate Cancer

NCT Number: NCT05169970
Phase: Phase 2
Trial Summary: The researchers are doing this study to find out if stereotactic body radiation therapy (SBRT) without androgen deprivation therapy (ADT) is an effective treatment approach for peo – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Memorial Sloan Kettering Cancer Center
Acronym:

Methods for Increasing Genetic Testing Uptake in Michigan

NCT Number: NCT05162846
Phase: NA
Trial Summary: The primary purpose of this study is to compare three interventions, two experimental and one standard of care (usual care), to see if the experimental interventions will increase – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of Michigan Rogel Cancer Center
Acronym: MiGHT

Massage for Prostate Cancer-Related Fatigue, mPROSTATE Study

NCT Number: NCT05067777
Phase: Phase 2
Trial Summary: This phase II trial investigates the effect of massage in decreasing prostate cancer-related fatigue. Massage therapy has well known health benefits. This trial aims to find out if – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of Utah|National Cancer Institute (NCI)
Acronym: mPROSTATE

Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score

NCT Number: NCT05050084
Phase: Phase 3
Trial Summary: This phase III trial uses the Decipher risk score to guide intensification (for higher Decipher gene risk) or de-intensification (for low Decipher gene risk) of treatment to better – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): NRG Oncology|National Cancer Institute (NCI)
Acronym:

Post-prostatectomy Radiation Therapy–Moderate Versus Ultra-hypofractionated (Also Known as Stereotactic Body Radiation Therapy [SBRT])

NCT Number: NCT05038332
Phase: Phase 2
Trial Summary: The primary purpose of this study is to compare the quality of life (QOL) reported by prostate cancer patients 2 years after treatment with ultra-hypofractionated post-prostatectom – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of Michigan Rogel Cancer Center
Acronym:

Diagnostic Performance Of Non-Endorectal Coil Multiparametric Magnetic Resonance Imaging Of Prostate With Flexible AIR Coil (DoNEMAC Study)

NCT Number: NCT05043012
Phase: Not Applicable
Trial Summary: Multiparametric MRI (mpMRI) of the prostate is an important tool for diagnosis of clinically significant prostate cancer (csPCa) in men with an elevated serum prostate specific ant – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): M.D. Anderson Cancer Center
Acronym:

Fluorescent Imaging of Nerves With Illuminare-1 During Surgery

NCT Number: NCT04983862
Phase: PHASE1
Trial Summary: This study will test the safety of using Illuminare-1 during standard surgery for prostate cancer. The study researchers will test increasing doses of Illuminare-1 to find the dose – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Memorial Sloan Kettering Cancer Center
Acronym:

A Study of MRI-guided High-dose Radiation Therapy in Prostate Cancer

NCT Number: NCT04997018
Phase: Phase 2
Trial Summary: One of the usual approaches to treating intermediate-risk prostate cancer is a type of radiation therapy called SBRT (stereotactic body radiation therapy). SBRT delivers higher tha – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Memorial Sloan Kettering Cancer Center
Acronym:

Robot-Assisted Radical Prostatectomy With or Without Vesicopexy in Patients With Prostate Cancer

NCT Number: NCT04981834
Phase: Not Applicable
Trial Summary: This phase III trial compares the effects of robot-assisted radical prostatectomy (RARP) with or without vesicopexy on urinary continence (a person’s ability to control their bladd – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of Southern California|National Cancer Institute (NCI)
Acronym:

Effectiveness of the SpaceOAR Vue System in Subjects With Prostate Cancer Being Treated With Stereotactic Body Radiotherapy

NCT Number: NCT04905069
Phase: Not Applicable
Trial Summary: To demonstrate the effectiveness of the SpaceOAR Vue System in reducing late gastrointestinal (GI) toxicity in subjects undergoing Stereotactic Body Radiotherapy (SBRT) to treat pr – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Boston Scientific Corporation
Acronym: SABRE

99mTc-PSMA-I&S Biodistribution in Patients With Prostate Cancer

NCT Number: NCT04857502
Phase: Early Phase 1
Trial Summary: This exploratory study conducted under the RDRC program studies the biodistribution of 99mTc-PSMA-I&S in patients with prostate cancer who undergo pelvic lymph node dissection. Pr – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Jonsson Comprehensive Cancer Center
Acronym:

Improving Care After Inherited Cancer Testing

NCT Number: NCT04763915
Phase: NA
Trial Summary: The IMPACT Study seeks to refine and evaluate the effectiveness of interventions on improving guideline-adherent cancer risk management (CRM) and family communication (FC) of genet – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Vanderbilt-Ingram Cancer Center
Acronym: IMPACT

Multiparametric Magnetic Resonance Imaging of the Prostate to Assess Disease Progression and Genomics in Patients Undergoing Active Surveillance for Prostate Cancer

NCT Number: NCT04692675
Phase: Not Applicable
Trial Summary: Active surveillance (AS) is a standard approach to treat low and intermediate risk prostate cancer. For AS, disease progression is monitored. AS uses biopsies, prostate specific an – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
Acronym:

To Evaluate if Green Tea Can be Effective in Reducing the Progression of Prostate Cancer in Men on Close Monitoring

NCT Number: NCT04597359
Phase: Phase 2
Trial Summary: This phase II trial studies how well green tea catechins work in preventing progression of prostate cancer from a low risk stage to higher risk stages in men who are on active surv – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): ECOG-ACRIN Cancer Research Group|National Cancer Institute (NCI)|Eastern Cooperative Oncology Group
Acronym:

Researching the Effect of Exercise on Cancer

NCT Number: NCT04589468
Phase: NA
Trial Summary: Researchers think that exercise may be able to prevent cancer from coming back by lowering ctDNA levels. The purpose of this study is to explore how aerobic exercise (exercise that – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Memorial Sloan Kettering Cancer Center
Acronym:

Testing the Effects of Low Dose Apalutamide on Prostate-Specific Antigen (PSA) Levels in Men Scheduled for Removal of the Prostate Gland

NCT Number: NCT04530552
Phase: Phase 2
Trial Summary: This phase IIa trial investigates the biomarker (plasma levels of PSA) of low-dose apalutamide in patients with prostate cancer confined in the prostate gland before surgery. Testo – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): National Cancer Institute (NCI)
Acronym:

Hypofractionated Accelerated Pelvic Nodal Radiotherapy (GCC 2048)

NCT Number: NCT04486755
Phase: Phase 1
Trial Summary: A phase I trial to determine the safety of delivering three sequentially shorter RT schedules (20, 16, and 12 fractions) of HypoFx pelvic nodal RT in combination with a HypoFx, sim – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): University of Maryland, Baltimore
Acronym:

The Impact of Low Pressure Pneumo in RARP II

NCT Number: NCT04394676
Phase: Not Applicable
Trial Summary: The purpose of this study is to evaluate clinical significance of low pressure pneumoperitoneum during robotically assisted radical prostatectomy (RAR – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Metro Health, Michigan
Acronym:

Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years

NCT Number: NCT04373564
Phase: PHASE4
Trial Summary: This study is a postmarketing requirement jointly carried out by four NDA holders (Bayer AG, Bracco, GE Healthcare and Guerbet) and the CRO IQVIA. The study aims to create detaile – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Guerbet
Acronym: ODYSSEY

Onco-primary Care Networking to Support TEAM-based Care

NCT Number: NCT04258813
Phase: NA
Trial Summary: The proposed ONE TEAM Study is an 18-month, cluster randomized controlled trial. This study will use a sequential multiple assignment randomized trial (SMART) design with a second – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Duke University
Acronym: ONE TEAM

Serial MRI Scans During Radiation Therapy

NCT Number: NCT04188535
Phase: Not Applicable
Trial Summary: This is a phase 1 study to determine the feasibility and utility of using serial magnetic resonance imaging (MRI) to assess treatment response during and after radiation therapy (s – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Dana-Farber Cancer Institute
Acronym: RELAY

Comparison of High-Dose Rate Brachytherapy and Stereotactic Ablative Radiotherapy as Monotherapy for the Treatment of Localized Prostate Cancer

NCT Number: NCT04253483
Phase: Phase 2
Trial Summary: This phase II trial compares high-dose rate brachytherapy and stereotactic ablative radiotherapy as monotherapy in treating patients with prostate cancer that has not spread to oth – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Rutgers, The State University of New Jersey|National Cancer Institute (NCI)
Acronym:

Nutrition and Exercise Interventions in Reducing Androgen Deprivation Therapy-Induced Obese Frailty in Prostate Cancer Survivors

NCT Number: NCT03880422
Phase: Not Applicable
Trial Summary: This trial studies how well nutrition and exercise interventions work in reducing androgen deprivation therapy-induced obese frailty in prostate cancer survivors. Individualized nu – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Roswell Park Cancer Institute
Acronym:

Methylphenidate and Exercise in Reducing Cancer-Related Fatigue in Patients With Prostate Cancer

NCT Number: NCT03772834
Phase: Phase 2|Phase 3
Trial Summary: This phase II/III trial studies how well methylphenidate and exercise work in reducing cancer-related fatigue in patients with prostate cancer. Methylphenidate is a type of central – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): M.D. Anderson Cancer Center|National Cancer Institute (NCI)
Acronym:

CyberKnife Dose Escalation Prostate Cancer Trial

NCT Number: NCT03822494
Phase: Not Applicable
Trial Summary: Stereotactic body radiation therapy (SBRT) has been employed in the treatment of prostate cancer. Multiple single institution experiences suggest high biochemical control rates wit – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Crozer-Keystone Health System
Acronym: CK-DESPOT

Multiparametric MRI in Evaluating Cancer Stage and Helping Treatment Planning in Patients With Prostate Cancer

NCT Number: NCT03697148
Phase: Not Applicable
Trial Summary: This phase II trial studies how well multiparametric magnetic resonance imaging (MRI) works in evaluating cancer stage and helping treatment planning in patients with prostate canc – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): ECOG-ACRIN Cancer Research Group|National Cancer Institute (NCI)|Eastern Cooperative Oncology Group
Acronym:

Stereotactic Body Radiotherapy for Stage I-III Prostate Cancer

NCT Number: NCT02334579
Phase: Not Applicable
Trial Summary: The purpose of this study is to find out the effects (good and bad) of highly focused radiation on you and your prostate cancer. The purpose of this evaluation is to see if this tr – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Swedish Medical Center
Acronym:

Focal Laser Ablation of Low to Intermediate Prostate Cancer Tumors

NCT Number: NCT02600156
Phase: Not Applicable
Trial Summary: The primary purpose of this study is to evaluate the feasibility and safety of MRI-guided focal laser ablation (Laser-Induced Interstitial Thermal Therapy, LITT) to treat low-risk – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Mayo Clinic
Acronym:

Evaluation of CyberKnife Stereotactic Radiotherapy in Prostate Cancer

NCT Number: NCT02016248
Phase: Not Applicable
Trial Summary: The purpose of this study is to determine the side effects and how effective CyberKnife stereotactic ablative body radiation (SABR) is in patients with prostate cancer. The CyberKn – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): MemorialCare Health System
Acronym:

MRI for Assessing Prostate Cancer Response

NCT Number: NCT01607008
Phase: Not Applicable
Trial Summary: Prostate cancer is one of most common cancers in America, affecting 1 in 6 men. External beam radiation therapy is one of the common methods to treat prostate cancer. Although radi – clinicaltrials.gov for more information and locations
Clinicaltrials.gov
Trial Sponsor(s): Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Acronym: NA_00067284

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Promise Registry - All Risk Levels

PROMISE is a nationwide registry of prostate cancer patients with inherited mutations by screening approximately 5,000 participants with a prostate cancer diagnosis. The PROMISE team is studying how these mutations affect patient outcomes.

This information is for educational purposes only and not intended as medical advice.
Patients should consult their medical doctor for advice and recommendations about specific clinical trials.

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